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The Glycemic Explorer Challenge – Test Your Knowledge

Beta-cell function—how much is lost and when?

Take the challenge and see how your knowledge of beta-cell function stacks up to that of your peers.

Title: Consequences of T2DM

Welcome to the Glycemic Explorer Challenge series! I’m Dr. Helen Baron your host—and a clinical and academic endocrinologist. I’ll be challenging you on your knowledge of the complexities in type 2 diabetes and treatment, and sharing with you how your answers compare with thousands of your peers who have taken the challenge at various national meetings and conferences.

So let’s dig in. In patients with type 2 diabetes, we’ve seen that negative consequences can occur early. So, let me ask you, what percentage of β-cell function do you think is typically lost by the time an individual is diagnosed with diabetes?

We have options ranging from 0 to 100%.

Before we go on, I’ll give you a few seconds to think about your answer and then we’ll see how your peers responded.

We see that while your peers’ answers were spread out among a number of options, just over half thought that 50% of beta-cell function was lost. And according to the United Kingdom Prospective Diabetes Study, they are correct.

Let’s look a little deeper. As we know, type 2 diabetes may have already progressed significantly by the time it’s diagnosed. Here we see that in the UKPDS study of over 4,200 patients with type 2 diabetes, beta-cell function declined about 50% over the approximate 10 years prior to diagnosis of type 2 diabetes.

And here’s the study design.

If you’re one of the folks who thought the number was higher, other studies have suggested beta-cell function loss of even greater than 50%.

For example, one study demonstrated beta-cell function loss as high as 75% by the time patients’ blood glucose level exceeded 140mg/dl.

So what does this mean for us as clinicians?

It’s been shown that poor glycemic control for an extended period of time can lead to long-term effects, including micro- and macrovascular complications. Due to the significant progression of type 2 diabetes, we know that early and intensive intervention may improve current and future outcomes.

So, when considering approaches for your patients who are uncontrolled, be sure to ask yourself, will your next move do enough?

Thanks for joining us. Look for more chances to challenge yourself with the other videos in this series.

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